Abstract :
Background: A lot of researches have been done to find an ideal adjuvant to bupivacaine in epidural anaesthesia that
inhibits intra and post operative pain and prolongs the duration of anaesthesia without any side effects. Study regarding
antinociceptive effect of magnesium in epidural route is very limited. Aim: This study was done to evaluate the onset,
extent and duration of sensory and motor block and side effects of clonidine and magnesium sulfate when used as an
adjuvant to bupivacaine in epidural anaesthesia in lower limb orthopedic surgery. Methods: A prospective randomized
double blind study was conducted on 60 patients of American society of anaesthesiologists status I and II, posted for lower
limb orthopedic surgery. All patients were randomly allocated into two groups of 30 each; group I was bupivacaine -
clonidine group (BC) and group II was bupivacaine – magnesium sulfate group (BM). Group I (BC) patients received 16 ml
of 0.5% bupivacaine and clonidine 2mcg/kg. Group II
Keyword :
Clonidine, Magnesium sulfate, Bupivacaine, Orthopedic.