Abstract :
Neuroendocrine neoplasms are defined as epithelial neoplasms with predominant neuroendocrine differentiation. Extremely rare site for neuroendocrine carcinoma are nasal cavity and paranasal sinuses and are aggressive neoplasm with a high recurrence rate and a tendency to metastasize.
A 19-year male presented to the department of Otorhinolaryngology with left nasal obstruction, persistent headache for nine months and on and off bleeding from left nasal cavity for 2 months. On examination of the nasal cavity, a gross deviation of nasal septum with a red, friable, gelatinous, polypoidal mass with a tendency to bleed was seen in the left nasal cavity. The patient underwent endoscopic excision of mass under GA. Specimen was sent for histopathological examination which exhibited the properties of Neuro-endocrine carcinoma.
Sinonasal NEC is an extremely rare malignancy. CT scan with intravenous contrast is the most effectual early imaging study, additionally MRI will further make a fine description of the tumor extension. Furthermore, Immunohisto-chemistry is an important tool that can be valuable in reaching a diagnosis. There is no clear recommendation regarding the treatment of the sinonasal neuroendocrine carcinoma, but the multimodal approach with proper counselling of patient is favoured and generally accepted.
Keyword :
Neuroendocrine, Paranasal sinus, Epistaxis, Carcinoma